An HLA- B27 blood test may help diagnose one of these conditions. The influence of HLA- B27 antigen on clinical, radiological and laboratory features of rheumatoid arthritis ( RA) was studied. How can the answer be improved?
HLA- B27 is a genetic marker. Thirty years after its discovery, 1, 2 the association between HLA- B27 and ankylosing spondylitis remains the strongest known relationship between a major histocompatibility complex. The group with B27 antigen comprised: 4 males and 20 females aged 28 to 71 and a group of patients free from B27 antigen consisted of 2 males and 21 females aged 26 to 69. HLA- B27 is a protein ( antigen) on cell surfaces that is associated with autoimmune disorders such as ankylosing spondylitis, reactive arthritis, juvenile rheumatoid arthritis, and anterior uveitis. Jan 18, · Whereas HLA- B27 accounts for over half of the genetic susceptibility, other genes involved in inflammation, such as ARTS1, IL23R and IL1A, have also been shown to be associated with susceptibility to AS and they may interact with HLA- B27.
Hla b27 artrita reumatoidă. HLA- B gene - Genetics Home Reference. In people with inflammatory arthritis of the spine and joints ( not osteoarthritis), a positive HLA- B27 test is associated with the presence of one of a group of.
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